| Identification | Back Directory | [Name]
EGFR/HER2-IN-12 | [CAS]
2237230-21-4 | [Synonyms]
EGFR/HER2-IN-12
Thieno[2,3-d]pyrimidin-4-amine, N-[3-chloro-4-(3-methylphenoxy)phenyl]-6-(4-nitrophenyl)- | [Molecular Formula]
C25H17ClN4O3S | [MOL File]
2237230-21-4.mol | [Molecular Weight]
488.95 |
| Chemical Properties | Back Directory | [Melting point ]
162-164 °C | [Boiling point ]
663.8±55.0 °C(predicted) | [density ]
1.431±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
4.71±0.40(predicted) |
| Hazard Information | Back Directory | [Uses]
EGFR/HER2-IN-12 (compound 14b) is a dual inhibitor of EGFR and HER2 with 81% and 51% inhibition at 10 μM. The toxicity of EGFR/HER2-IN-12 to cancer cells A431 and MDA-MB-361 was not significant[1]. | [References]
[1] Milik SN, et al. Surmounting the resistance against EGFR inhibitors through the development of thieno[2,3-d]pyrimidine-based dual EGFR/HER2 inhibitors. Eur J Med Chem. 2018 Jul 15;155:316-336. DOI:10.1016/j.ejmech.2018.06.011 |
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