| Identification | Back Directory | [Name]
2-Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-5-(dimethylamino)-6-(2-phenylethynyl)-, hydrochloride (1:1) | [CAS]
2237925-62-9 | [Synonyms]
DMA-135
DMA-135 hydrochloride
2-Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-5-(dimethylamino)-6-(2-phenylethynyl)-, hydrochloride (1:1) | [Molecular Formula]
C16H18ClN7O | [MOL File]
2237925-62-9.mol | [Molecular Weight]
359.82 |
| Hazard Information | Back Directory | [Uses]
DMA-135 hydrochloride inhibits enterovirus 71 (EV71) IRES-dependent translation and replication. DMA-135 hydrochloride binds to enterovirus 71 (EV71) SLII domain with moderately high affinity (KD= 520 nM). DMA-135 hydrochloride has no significant toxicity in cell-based studies[1]. DMA-135 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [Biological Activity]
DMA-135 is a cell penetrant and potent inhibitor of human enterovirus 71 (EV71) translation and replication th at targets the IRES domain of EV71. DMA-135 binds allosterically to EV71 SLII RNA and stabilizes ternary complex consisting of AUF1-SLII-DMA-135. Alsoprevious data indicate th at DMA-135 exhibit comparable affinity to HIV-1-TAR and HIV-2-TAR. | [References]
[1] Davila-Calderon J, et al. IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex. Nat Commun. 2020;11(1):4775. Published 2020 Sep 22. DOI:10.1038/s41467-020-18594-3 |
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| Company Name: |
Merck KGaA
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21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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