ChemicalBook--->CAS DataBase List--->2240191-12-0

2240191-12-0

Request For Quotation
2240191-12-0 Structure

2240191-12-0 Structure
IdentificationBack Directory
[Name]

3-Pyridinecarboxamide, N-[4-(chlorodifluoromethoxy)phenyl]-6-[(3R)-3-hydroxy-1-pyrrolidinyl]-5-(4-isothiazolyl)-
[CAS]

2240191-12-0
[Synonyms]

BCR-ABL-IN-3
3-Pyridinecarboxamide, N-[4-(chlorodifluoromethoxy)phenyl]-6-[(3R)-3-hydroxy-1-pyrrolidinyl]-5-(4-isothiazolyl)-
[Molecular Formula]

C20H17ClF2N4O3S
[MOL File]

2240191-12-0.mol
[Molecular Weight]

466.89
Chemical PropertiesBack Directory
[Boiling point ]

543.9±50.0 °C(Predicted)
[density ]

1.519±0.06 g/cm3(Predicted)
[pka]

10.83±0.70(Predicted)
Hazard InformationBack Directory
[Uses]

BCR-ABL-IN-3 is a potent and irreversible Bcr-Abl inhibitor with an IC50 of ≤100 nM for Ba/F3Bcr-AblT3151. BCR-ABL-IN-3 has anti-cancer activity[1].
[in vivo]

BCR-ABL-IN-3 (compound 7; 15 mg/kg; twice a day; for 19 days) has good antitumor effect in female NOD/SCID mice of 7-8 weeks weighing 21.8 g with Ba/F3Bcr-AblT3151 cells[1].
BCR-ABL-IN-3 (2 mg/kg for IV or 20mg/kg for PO) has a Cmax of 5485 ng/mL and an AUC of 5450 h?ng/mL for IV in male Sprague Dawley rats of 7-8 weeks old weighing 210 g[1].

[IC 50]

Ba/F3Bcr-AblT3151: ≤100 nM (IC50)
[References]

[1] Hanyi Wang, et al. (hetero)arylamide compound for inhibiting protein kinase activity. WO2018133826A1.
2240191-12-0 suppliers list
Company Name: TargetMol Chemicals Inc.  
Telephone: 15002134094
Website: https://www.targetmol.cn/
Tags:2240191-12-0 Related Product Information
896466-04-9 943319-70-8 185039-91-2 895519-90-1 1492952-76-7 1800398-38-2