| Chemical Properties | Back Directory | [density ]
1.38±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
13.35±0.20(Predicted) | [color ]
White to off-white | [Sequence]
{3-Cyclohexylpropionyl}-Leu-Leu-{Dbu}-Pro-Arg-Asn-NH2 |
| Hazard Information | Back Directory | [Uses]
CPN-219, a next-generation hexapeptidic NMUR2 agonist, achieves a dose-dependent and selective activation of NMUR2 with an EC50 value of 2.2 nM[1]. | [in vivo]
CPN-219 (25-250 μg; intranasal administration) suppresses body weight gain of mice in a dose-dependent manner. In contrast, intraperitoneal injection (250 μg) is ineffective[1]. | Animal Model: | ddY mice[1]. | | Dosage: | 250, 100, 25 μg/mouse. | | Administration: | Applied to the nasal cavity; at days 1 and 4 | | Result: | Suppressed body weight gain of mice in a dose-dependent manner. |
| [IC 50]
NMUR2 | [References]
[1] Kentaro Takayama, et al. A chemically stable peptide agonist to neuromedin U receptor type 2. Bioorg Med Chem. 2020 May 15;28(10):115454. DOI:10.1016/j.bmc.2020.115454 |
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| Company Name: |
Fuan Bio
|
| Tel: |
15002819872 |
| Website: |
fuanbio.com |
| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
|