| Identification | Back Directory | [Name]
cyclobuxine | [CAS]
2241-90-9 | [Synonyms]
NSC 91720
NSC-102244
cyclobuxine
(3beta,5alpha,16alpha,20S)-14-Methyl-3,20-bis(methylamino)-4-methylene-9,19-cyclopregnan-16-ol | [Molecular Formula]
C25H42N2O | [MDL Number]
MFCD01745535 | [MOL File]
2241-90-9.mol | [Molecular Weight]
386.614 |
| Chemical Properties | Back Directory | [Melting point ]
236-238℃ | [alpha ]
D23 +98° (chloroform) | [Boiling point ]
494.2±40.0℃ (760 Torr) | [density ]
1.08±0.1 g/cm3 (20 ºC 760 Torr) | [Fp ]
53.5±17.9℃ | [pka]
15.11±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
Cyclobuxine D is a steroidal alkaloid extracted from Buxus microphylla. Cyclobuxine D has a significant bradycardic effect in the rat heart and an inhibitory action on acetylcholine and Ba++?induced contraction of the longitudinal muscle isolated from the rabbit jejunum[1][2]. | [Definition]
ChEBI: Cyclobuxine D is a steroid alkaloid. | [References]
[1] . A. Eshonov, et al. Alkaloids of Buxus sempervirens, Crystal and Molecular Structure of Cyclobuxine-D and Imperialine. Chemistry of Natural Compounds. 12 January 2014. 49:11791182.
[2] Kwon, Jun-Tack, et al. Effects of Cyclobuxine D on Drug-Induced Contractions of the Isolated Rat Uterine Muscle and Potassium-Activated Calcium Channels in an Intestinal Smooth Muscle. The Korean Journal of Pharmacology. 1988. 24 (1): 103-109. |
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