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2241573-22-6

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2241573-22-6 Structure

2241573-22-6 Structure

Identification	Back Directory
[Name] Benzonitrile, 2-fluoro-4-[5-(2-methyl-1,3-dioxolan-2-yl)-3-pyridinyl]-
[CAS] 2241573-22-6
[Synonyms] Benzonitrile, 2-fluoro-4-[5-(2-methyl-1,3-dioxolan-2-yl)-3-pyridinyl]-
[Molecular Formula] C16H13FN2O2
[MOL File] 2241573-22-6.mol
[Molecular Weight] 284.29

Chemical Properties	Back Directory
[Boiling point ] 461.2±45.0 °C(predicted)
[density ] 1.31±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] 3.45±0.24(predicted)

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[Uses] CYP11B2-IN-2 (Compound 10k) is an inhibitor for enzyme aldosterone synthase CYP11B2 with an IC50 of 0.3 nM. CYP11B2-IN-2 CYP11B-IN-2 is labeled with 18F and can be used as a positron emission tomography (PET) tracer for the diagnosis of primary aldosteronism[1].
[IC 50] CYP11B2: 0.3 nM (IC₅₀); CYP11B1: 3.8 nM (IC₅₀)
[References] [1] Maier P, et al., Fluorinated aldosterone synthase (CYP11B2)-inhibitors for differential diagnosis between bilateral and unilateral conditions of primary aldosteronism. Bioorg Med Chem Lett. 2023 Nov 15;96:129501. DOI:10.1016/j.bmcl.2023.129501

2241573-22-6 suppliers list

Company Name:	Shanghai Beckham Medical Technology Co., Ltd
Tel:	13816613772
Website:	www.chemicalbook.com/ShowSupplierProductsList16976/0_EN.htm

Company Name:	TargetMol Chemicals Inc.
Tel:	15002134094
Website:	https://www.targetmol.cn/

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