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2241668-58-4

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2241668-58-4 Structure

2241668-58-4 Structure

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[Name] 6H-Purin-6-one, 2-amino-8-[1-(21-chloro-3,6,9,12,15-pentaoxaheneicos-1-yl)-1H-pyrazol-4-yl]-9-[(4-fluorophenyl)methyl]-1,9-dihydro-
[CAS] 2241668-58-4
[Synonyms] 6H-Purin-6-one, 2-amino-8-[1-(21-chloro-3,6,9,12,15-pentaoxaheneicos-1-yl)-1H-pyrazol-4-yl]-9-[(4-fluorophenyl)methyl]-1,9-dihydro-
[MOL File] 2241668-58-4.mol
[Molecular Weight] 664.17

Chemical Properties	Back Directory
[Boiling point ] 816.5±75.0 °C(predicted)
[density ] 1.34±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] 2.47±0.20(predicted)

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[Uses] 2G-HaloAUTAC (Compound tt44) is a second-generation autophagy-targeting chimera (2G-HaloAUTAC) that improves the activity of AUTACs by replacing the L-Cysteine ??(L-Cys) linker with other structures. 2G-HaloAUTAC exhibits degradation activity against EGFP-HaloTag protein through an autophagic mechanism[1].
[References] [1] Takahashi D, et al., Second-Generation AUTACs for Targeted Autophagic Degradation. J Med Chem. 2023 Sep 14;66(17):12342-12372. DOI:10.1021/acs.jmedchem.3c00861

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Company Name:	TargetMol Chemicals Inc.
Tel:	15002134094
Website:	https://www.targetmol.cn/

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