| Identification | Back Directory | [Name]
Memogain | [CAS]
224169-27-1 | [Synonyms]
Memogain
GLN-1062
6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, 6-benzoate, (4aS,6R,8aS)- | [Molecular Formula]
C24H25NO4 | [MOL File]
224169-27-1.mol | [Molecular Weight]
391.46 |
| Chemical Properties | Back Directory | [Boiling point ]
523.2±50.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
7.78±0.40(Predicted) | [color ]
White to yellow | [InChI]
InChI=1S/C24H25NO4/c1-25-13-12-24-11-10-18(28-23(26)16-6-4-3-5-7-16)14-20(24)29-22-19(27-2)9-8-17(15-25)21(22)24/h3-11,18,20H,12-15H2,1-2H3/t18-,20-,24-/m0/s1 | [InChIKey]
JKVNJTYHRABHIY-WXVUKLJWSA-N | [SMILES]
N1(C)CC2=CC=C(OC)C3O[C@]4([H])[C@@](C=C[C@H](OC(=O)C5=CC=CC=C5)C4)(C2=3)CC1 |
| Hazard Information | Back Directory | [Uses]
Galantamine Benzoate-D3 is an isotopic labelled compound of Galantamine Benzoate, a pro-drug that slows down plaque deposition and ameliorates behavior in 5X familial Alzheimer's disease mice. | [in vivo]
Benzgalantamine (0.3-3 mg/kg, intranasal, twice a day for 2 weeks) improves cognitive function by promoting neurogenesis in the hippocampus, specifically in the dentate gyrus and CA1 regions of the hippocampus in rats models[2]. | Animal Model: | Sprague Dawley rats models[2] | | Dosage: | 0.3-3 mg/kg | | Administration: | intranasal, twice a day for 2 weeks | | Result: | Increased the number of newly generated cells and immunolabeling of synaptic markers in the dentate gyrus and CA1 regions of the hippocampus. |
| [storage]
Store at -20°C |
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