| Identification | Back Directory | [Name]
2-Propen-1-one, 1-[7-[6-cyclopropyl-2-[[1-(3-methoxypropyl)-4-piperidinyl]oxy]-7-(5-methyl-1H-indazol-4-yl)-8-(2,2,2-trifluoroethoxy)-4-quinazolinyl]-2,7-diazaspiro[3.5]non-2-yl]- | [CAS]
2241719-73-1 | [Synonyms]
ASP2453
2-Propen-1-one, 1-[7-[6-cyclopropyl-2-[[1-(3-methoxypropyl)-4-piperidinyl]oxy]-7-(5-methyl-1H-indazol-4-yl)-8-(2,2,2-trifluoroethoxy)-4-quinazolinyl]-2,7-diazaspiro[3.5]non-2-yl]- | [Molecular Formula]
C40H48F3N7O4 | [MOL File]
2241719-73-1.mol | [Molecular Weight]
747.85 |
| Chemical Properties | Back Directory | [Boiling point ]
855.8±75.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
12.36±0.40(Predicted) | [color ]
White to yellow | [InChIKey]
VEXDXXFHISGELS-UHFFFAOYSA-N | [SMILES]
C(N1CC2(CCN(C3=C4C(=NC(OC5CCN(CCCOC)CC5)=N3)C(OCC(F)(F)F)=C(C3=C(C)C=CC5=C3C=NN5)C(C3CC3)=C4)CC2)C1)(=O)C=C |
| Hazard Information | Back Directory | [Uses]
ASP2453 is a potent, selective and covalent KRAS G12C inhibitor. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC50 value of 40 nM. | [Biological Activity]
ASP2453 is a potent, selective and covalent KRAS G12C inhibitor. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC50 value of 40 nM. | [IC 50]
KRas G12C: 40 nM (IC50) | [References]
[1]. Nakayama A, et al. Characterisation of a novel KRAS G12C inhibitor ASP2453 that shows potent anti-tumour activity in KRAS G12C-mutated preclinical models. Br J Cancer. 2021 Nov 18. |
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