| Hazard Information | Back Directory | [Uses]
Depemokimab (GSK-3511294) is a long-acting anti-IL-15 monoclonal antibody. Depemokimab can be used for research of asthma[1][2]. | [in vivo]
Depemokimab (PK assay in cynomolgus monkeys) shows an approximately 2-fold reduction in clearance compared with Mepolizumab (HY-P9945), and shows an IL-5 binding affinity approximately 30-fold greater than Mepolizumab[2].
| [References]
[1] Calzetta L, et al. Investigational Treatments in Phase I and II Clinical Trials: A Systematic Review in Asthma. Biomedicines. 2022 Sep 19;10(9):2330. DOI:10.3390/biomedicines10092330
[2] Singh D, et al. A Phase 1 study of the long-acting anti-IL-5 monoclonal antibody GSK3511294 in patients with asthma. Br J Clin Pharmacol. 2022 Feb;88(2):702-712. DOI:10.1111/bcp.15002 |
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