| Identification | Back Directory | [Name]
Benzoic acid, 4-(4-quinolinylamino)-, 2-(4-pyridinylmethylene)hydrazide | [CAS]
2243355-51-1 | [Synonyms]
4-PQBH
Benzoic acid, 4-(4-quinolinylamino)-, 2-(4-pyridinylmethylene)hydrazide | [Molecular Formula]
C22H17N5O | [MOL File]
2243355-51-1.mol | [Molecular Weight]
367.4 |
| Hazard Information | Back Directory | [Uses]
4-PQBH is a potent Nur77 binder (KD=1.17 μM). 4-PQBH extensively induces caspase-independent cytoplasmic vacuolization and paraptosis through Nur77-mediated ER stress and autophagy. 4-PQBH can be used for cancer research[1]. | [IC 50]
Nur77/NR4A1 | [References]
[1] Baicun Li, et al. Discovery of a Nur77-mediated cytoplasmic vacuolation and paraptosis inducer (4-PQBH) for the treatment of hepatocellular carcinoma. Bioorg Chem. 2022 Apr;121:105651. DOI:10.1016/j.bioorg.2022.105651 |
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