| Identification | Back Directory | [Name]
DW14800 | [CAS]
2243709-60-4 | [Synonyms]
DW14800
6-Isoquinolinecarboxamide, N-[3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-2-[4-(dimethylamino)benzoyl]-1,2,3,4-tetrahydro- | [Molecular Formula]
C31H36N4O3 | [MDL Number]
MFCD32067960 | [MOL File]
2243709-60-4.mol | [Molecular Weight]
512.64 |
| Chemical Properties | Back Directory | [Boiling point ]
754.9±60.0 °C(Predicted) | [density ]
1.229±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
13.91±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
DW14800 is a protein arginine methyltransferase 5 (PRMT5) inhibitor. It reduces H4R3me2s levels and enhances the transcription of HNF4α, but does not alter PRMT5 expression. DW14800 has anti-cancer activity. | [Uses]
DW14800 is a protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 17 nM. DW14800 reduces H4R3me2s levels and enhances the transcription of HNF4α, but does not alter PRMT5 expression. Anti-cancer activity[1]. | [IC 50]
PRMT5 | [storage]
Store at -20°C | [References]
[1] Zheng BN, et al. Targeting PRMT5 Activity Inhibits the Malignancy of Hepatocellular Carcinoma by Promoting the Transcription of HNF4α. Theranostics. 2019 Apr 13;9(9):2606-2617. DOI:10.7150/thno.32344 |
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