| Chemical Properties | Back Directory | [Boiling point ]
607.4±55.0 °C(Predicted) | [density ]
1.346±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 83.33 mg/mL (192.04 mM) | [form ]
Solid | [pka]
3.00±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
G907 is a selective antagonist of ATP-binding cassette (ABC) transporter MsbA with anti-microbial activity. G907 inhibits E. coli MsbA with an IC50 value of 18 nM. G907 traps MsbA in an inward-facing, lipopolysaccharide-bound conformation by wedging into an architecturally conserved transmembrane pocket[1][2]. | [References]
[1] Ho H, et al. Structural basis for dual-mode inhibition of the ABC transporter MsbA. Nature. 2018 May;557(7704):196-201. DOI:10.1038/s41586-018-0083-5
[2] Guo D, et al. Energetics of lipid transport by the ABC transporter MsbA is lipid dependent. Commun Biol. 2021 Dec 9;4(1):1379. DOI:10.1038/s42003-021-02902-8 |
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