| Identification | Back Directory | [Name]
2-Quinoxaline-5,6,7,8-d4-carboxylic acid, 3-methyl- | [CAS]
2244217-93-2 | [Synonyms]
2-Quinoxaline-5,6,7,8-d4-carboxylic acid, 3-methyl- | [Molecular Formula]
C10H4D4N2O2 | [MOL File]
2244217-93-2.mol | [Molecular Weight]
192.207 |
| Hazard Information | Back Directory | [Uses]
3-Methyl-2-quinoxalinecarboxylic acid-d4 is the deuterium labeled 3-Methyl-2-quinoxalinecarboxylic acid. 3-Methyl-2-quinoxalinecarboxylic acid (MQCA), an important N-oxide reductive metabolite of Quinocetone or Olaquindox, potently inhibits the growth of Chang liver cells through S phase arrest of the cell cycle[1]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Keyu Zhang , et al. Cytotoxicity and Genotoxicity of 1,4-bisdesoxyquinocetone, 3-methylquinoxaline-2-carboxylic Acid (MQCA) in Human Hepatocytes. Res Vet Sci. 2012 Dec;93(3):1393-401. DOI:10.1016/j.rvsc.2012.06.012 |
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