| Chemical Properties | Back Directory | [Boiling point ]
806.1±65.0 °C(Predicted) | [density ]
1.43±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 250 mg/mL (474.01 mM) | [form ]
Solid | [pka]
12.36±0.46(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Description]
BI-4916 is a prodrug of the co-factor nicotinamide adenine dinucleotide (NADH/NAD+)-competitive PHGDH inhibitor BI-4924, which has shown high selectivity against the majority of other dehydrogenase targets. | [Uses]
BI-4916 is a proagent of BI-4924. BI-4924 is a NADH/NAD+-competitive PHGDH inhibitor[1]. | [storage]
Store at -20°C | [References]
[1] Weinstabl H, et al. Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor BI-4924 Disrupts Serine Biosynthesis. J Med Chem. 2019 Jul 31. DOI:10.1021/acs.jmedchem.9b00718
[2] Kiweler N, et al. Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis. Nat Commun. 2022 May 16;13(1):2699. DOI:10.1038/s41467-022-30363-y
[3] Becker B, et al. Serine metabolism is crucial for cGAS-STING signaling and viral defense control in the gut. iScience. 2024 Feb 8;27(3):109173. DOI:10.1016/j.isci.2024.109173 |
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