| Identification | Back Directory | [Name]
Pregna-1,4-diene-3,20-dione-4,6,11,12,12-d5, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11β,16β)- | [CAS]
2244574-92-1 | [Synonyms]
Pregna-1,4-diene-3,20-dione-4,6,11,12,12-d5, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11β,16β)- | [Molecular Formula]
C22H29FO5 | [MOL File]
2244574-92-1.mol | [Molecular Weight]
392.47 |
| Hazard Information | Back Directory | [Uses]
Betamethasone-d5-1 is deuterium labeled Betamethasone. Betamethasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone accelerates fetal lung maturation and induces gene expression and apoptosis[1][2][3][4]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Schwab M, et, al. Effects of betamethasone administration to the fetal sheep in late gestation on fetal cerebral blood flow. J Physiol. 2000 Nov 1;528(Pt 3):619-32. DOI:10.1111/j.1469-7793.2000.00619.x
[3] Xie W, et, al. Betamethasone affects cerebral expressions of NF-kappaB and cytokines that correlate with pain behavior in a rat model of neuropathy. Ann Clin Lab Sci. Winter 2006;36(1):39-46. PMID:16501235
[4] Kubin ME, et, al. Clinical Efficiency of Topical Calcipotriol/Betamethasone Treatment in Psoriasis Relies on Suppression of the Inflammatory TNFα - IL-23 - IL-17 Axis. Acta Derm Venereol. 2017 Apr 6;97(4):449-455. DOI:10.2340/00015555-2579
[5] Hofmann TH, et, al. Various glucocorticoids differ in their ability to induce gene expression, apoptosis and to repress NF-kappaB-dependent transcription. FEBS Lett. 1998 Dec 28;441(3):441-6. DOI:10.1016/s0014-5793(98)01609-3 |
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