| Identification | Back Directory | [Name]
3-Isoxazolecarboxylic acid, 4-(3',5'-dichloro-4'-hydroxy[1,1'-biphenyl]-3-yl)-5-methyl- | [CAS]
2244622-44-2 | [Synonyms]
3-Isoxazolecarboxylic acid, 4-(3',5'-dichloro-4'-hydroxy[1,1'-biphenyl]-3-yl)-5-methyl- | [Molecular Formula]
C17H11Cl2NO4 | [MOL File]
2244622-44-2.mol | [Molecular Weight]
364.18 |
| Chemical Properties | Back Directory | [Boiling point ]
511.5±50.0 °C(Predicted) | [density ]
1.473±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [pka]
3.09±0.36(Predicted) |
| Hazard Information | Back Directory | [Uses]
MptpB-IN-1 (Compound 13) is a potent and orally active inhibitor of MptpB. Mycobacterium tuberculosis protein-tyrosine-phosphatase B (MptpB) is a secreted virulence factor that subverts antimicrobial activity in the host. MptpB-IN-1 reduces multidrug-resistant mycobacterium tuberculosis survival and infection burden[1]. | [storage]
Store at -20°C | [References]
[1] Vickers CF, et al. Structure-Based Design of MptpB Inhibitors That Reduce Multidrug-Resistant Mycobacterium tuberculosis Survival and Infection Burden in Vivo. J Med Chem. 2018;61(18):8337-8352. DOI:10.1021/acs.jmedchem.8b00832 |
|
|