| Identification | Back Directory | [Name]
Stearoyl-L-carnitine-d3 (chloride) | [CAS]
2245711-27-5 | [Synonyms]
Stearoyl-L-carnitine-d3 (chloride)
(R)-3-carboxy-N,N-dimethyl-N-(methyl-d3)-2-(stearoyloxy)propan-1-aminium,monochloride | [Molecular Formula]
C25H45ClD3NO3 | [MOL File]
2245711-27-5.mol | [Molecular Weight]
449.125 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 20 mg/ml,DMSO: 14 mg/ml,Ethanol: 20 mg/ml | [form ]
A solid | [color ]
White to light yellow | [Appearance]
white solid | [Stability:]
Hygroscopic | [InChI]
1S/C26H51NO3.ClH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(28)21-24(22-26(29)30)23-27(2,3)4;/h24H,5-23H2,1-4H3;1H/t24-;/m1./s1/i2D3; | [InChIKey]
FHYDBUBEZJDPMT-CVTUNGPQSA-N | [SMILES]
[O-]C(C[C@@H](CC(CCCCCCCCCCCCCCCCC)=O)C[N+](C)(C([2H])([2H])[2H])C)=O.Cl |
| Hazard Information | Back Directory | [Description]
Stearoyl-L-carnitine-d3 (chloride) is intended for use as an internal standard for the quantification of stearoyl-L-carnitine (Item No. 26556) by GC- or LC-MS. Stearoyl-L-carnitine is a naturally occurring long-chain acylcarnitine. It inhibits sodium-dependent [3H]carnitine uptake in human proximal convoluted tubular (HPCT) cells by 52% when used at a concentration of 500 μM. It also inhibits lecithin:cholesterol acyltransferase activity in rat, but not human, plasma when used at a concentration of 500 μM. Plasma levels of stearoyl-L-carnitine are decreased in patients with chronic fatigue syndrome and increased in patients with end-stage renal disease. | [Uses]
Stearoyl-L-carnitine-d3 Hydrochloride is labelled Stearoyl Carnitine (S686515), A carnitine ester which was tested for its ability to inhibit protein kinase C (PKC). | [IC 50]
GlyT2 | [storage]
Store at -20°C | [References]
[1] WEI HUANG . Carnitine transport and its inhibition by sulfonylureas in human kidney proximal tubular epithelial cells[J]. Biochemical pharmacology, 1999, 58 8: Pages 1361-1370. DOI: 10.1016/s0006-2952(99)00219-1
[2] BELL F P. Carnitine esters: Novel inhibitors of plasma lecithin: Cholesterol acyltransferase in experimental animals but not in man (Homo sapiens)[J]. International Journal of Biochemistry, 1983, 15 2: Pages 133-136. DOI: 10.1016/0020-711x(83)90053-8 |
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