| Identification | Back Directory | [Name]
SS-208 | [CAS]
2245942-72-5 | [Synonyms]
SS-208
3-Isoxazolecarboxamide, 5-[2-[(3,4-dichlorobenzoyl)amino]ethyl]-N-hydroxy- | [Molecular Formula]
C13H11Cl2N3O4 | [MDL Number]
MFCD32201105 | [MOL File]
2245942-72-5.mol | [Molecular Weight]
344.15 |
| Chemical Properties | Back Directory | [density ]
1.507±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C,unstable in solution, ready to use. | [solubility ]
DMF: 1mg/mL,DMSO: 1mg/mL,Ethanol: 30mg/mL,Ethanol:PBS (pH 7.2) (1:2): 0.3mg/mL | [form ]
A crystalline solid | [pka]
7.69±0.42(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SS-208 is a selective HDAC6 inhibitor, with an IC50 of 12 nM. SS-208 possesses anti-tumor activity in melanoma[1]. | [in vivo]
SS-208 (25 mg/kg, ip) significantly reduces the tumor growth in melanoma murine model[1]. | Animal Model: | C57BL/6 mice injected immunogenic murine SM1 melanoma cells subcutaneously[1]. | | Dosage: | 25 mg/kg. | | Administration: | IP on day 4, 7, 12, 15 and 18. | | Result: | Significantly reduced the tumor growth. |
| [IC 50]
HDAC6: 12 nM (IC50); HDAC8: 1.23 μM (IC50); HDAC1: 1.39 μM (IC50); HDAC11: 5.12 μM (IC50); HDAC5: 6.91 μM (IC50); HDAC7: 8.34 μM (IC50) | [storage]
Store at -20°C,unstable in solution, ready to use. | [References]
[1] Shen S, et al. Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models. J Med Chem. 2019 Sep 4. DOI:10.1021/acs.jmedchem.9b00946 |
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| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|