| Identification | Back Directory | [Name]
Fz7-21 | [CAS]
2247635-23-8 | [Synonyms]
Fz7-21
(Ac)-LPSDDLEFWCHVMY-NH2
Ac-Leu-Pro-Ser-Asp-Asp-Leu-Glu-Phe-Trp-Cys-His-Val-Met-Tyr-NH2 | [Molecular Formula]
C83H114N18O23S2 | [MOL File]
2247635-23-8.mol | [Molecular Weight]
1796.05 |
| Chemical Properties | Back Directory | [Boiling point ]
2088.7±65.0 °C(Predicted) | [density ]
1.358±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.15±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs the function of FZD7 in Wnt–β-catenin signalling and stem cell function in intestinal organoids[1][2]. | [storage]
-20°C | [References]
[1] Nile AH, et, al. A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nat Chem Biol. 2018 Jun;14(6):582-590. DOI:10.1038/s41589-018-0035-2
[2] Larasati Y, et, al. Unlocking the Wnt pathway: Therapeutic potential of selective targeting FZD7 in cancer. Drug Discov Today. 2022 Mar;27(3):777-792. DOI:10.1016/j.drudis.2021.12.008 |
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