| Identification | Back Directory | [Name]
P-gp modulator 1 | [CAS]
2249749-39-9 | [Synonyms]
P-gp modulator 1
P gp modulator 1,Pgp modulator 1
Carbamic acid, N-[6-[[(3β,12β,20S,24R)-20,24-epoxy-12,25-dihydroxydammaran-3-yl]amino]-6-oxohexyl]-, 1,1-dimethylethyl ester | [Molecular Formula]
C41H72N2O6 | [MDL Number]
MFCD32067892 | [MOL File]
2249749-39-9.mol | [Molecular Weight]
689.02 |
| Chemical Properties | Back Directory | [Boiling point ]
769.3±60.0 °C(Predicted) | [density ]
1.10±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
12.90±0.46(Predicted) |
| Hazard Information | Back Directory | [Uses]
P-gp modulator 1 is a high affinity, orally available modulator of P-glycoprotein (Pgp), can reverse the Pgp-mediated multidrug resistance ((MDR)[1]. | [References]
[1] Ren Q, et al. Design, synthesis, and discovery of ocotillol-type amide derivatives as orally available modulators of P-glycoprotein-mediated multidrug resistance. Eur J Med Chem. 2019 Jan 1;161:118-130. DOI:10.1016/j.ejmech.2018.10.038 |
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