| Identification | Back Directory | [Name]
Spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine, N-[(3-chlorophenyl)methyl]-, hydrochloride (1:1) | [CAS]
2250025-95-5 | [Synonyms]
Spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine, N-[(3-chlorophenyl)methyl]-, hydrochloride (1:1) | [Molecular Formula]
C19H22Cl2N4 | [MOL File]
2250025-95-5.mol | [Molecular Weight]
377.31 |
| Hazard Information | Back Directory | [Uses]
Liproxstatin-1 hydrochloride is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC50=22 nM)[1]. | [Biological Activity]
Liproxstatin-1 hydrochloride is a potent ferroptosis inhibitor (IC50 = 22 nM). Protects human renal proximal tubule cells from 1S,3R-RSL3 -induced cell death in vitro. Inhibits acute renal failure and prolongs survival in Gpx4 knockdown mice. Also mitigates tissue damage in an in vivo hepatic ischemia/reperfusion model. | [in vivo]
Liproxstatin-1 (10 mg/kg, i.p.) suppresses ferroptosis in human cells, Gpx4-/- kidney and in an ischaemia/reperfusion-induced tissue injury model[1]. | [storage]
Store at -20°C | [References]
[1] Friedmann Angeli JP, et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 2014 Dec;16(12):1180-91. DOI:10.1038/ncb3064
[2] Zilka O, et al. On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death. ACS Cent Sci. 2017 Mar 22;3(3):232-243 DOI:10.1021/acscentsci.7b00028 |
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