| Identification | Back Directory | [Name]
TD-106 | [CAS]
2250288-69-6 | [Synonyms]
TD-106
2,6-Piperidinedione, 3-(5-amino-4-oxo-1,2,3-benzotriazin-3(4H)-yl)- | [Molecular Formula]
C12H11N5O3 | [MDL Number]
MFCD31813761 | [MOL File]
2250288-69-6.mol | [Molecular Weight]
273.25 |
| Hazard Information | Back Directory | [Uses]
TD-106 is a cereblon (CRBN) modulator, which can be used for targeted protein degradation. BRD4 PROTACs with TD-106 induce BRD4 degradation[1]. | [in vivo]
TD-106 (50 mg/kg; intraperitoneally; q.d. for 14 days) possesses anti-myeloma activity in SCID mice with TMD-8 xenograft model. | Animal Model: | Female SCID (CB-17/IcrCri-scid) mice with TMD-8 xenograft model[1] | | Dosage: | 50 mg/kg | | Administration: | Intraperitoneally (i.p.); q.d. for 14 days | | Result: | Treatment inhibited tumor growth during this duration. |
| [IC 50]
Cereblon | [References]
[1] Kim SA, et al. A novel cereblon modulator for targeted protein degradation. Eur J Med Chem. 2019 Mar 15;166:65-74. DOI:10.1016/j.ejmech.2019.01.023 |
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