| Identification | Back Directory | [Name]
IDRA 21 | [CAS]
22503-72-6 | [Synonyms]
IDRA 21
AMPAKINE
IDRA 21,98%
7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE
7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE
7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE S,S-DIOXIDE
7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
2H-1,2,4-Benzothiadiazine,7-chloro-3,4-dihydro-3-Methyl-, 1,1-dioxide
7-chloro-3-methyl-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide | [EINECS(EC#)]
1592732-453-0 | [Molecular Formula]
C8H9ClN2O2S | [MDL Number]
MFCD00270874 | [MOL File]
22503-72-6.mol | [Molecular Weight]
232.69 |
| Chemical Properties | Back Directory | [Appearance]
white to off-white crystalline powder | [Melting point ]
209 °C(Solv: acetic acid (64-19-7)) | [Boiling point ]
405.1±55.0 °C(Predicted) | [density ]
1.394±0.06 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
DMSO (Slightly), Methanol (Slightly, Sonicated) | [form ]
Solid | [pka]
9.78±0.40(Predicted) | [color ]
Off-White to Pale Yellow | [InChI]
InChI=1S/C8H9ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-5,10-11H,1H3 | [InChIKey]
VZRNTCHTJRLTMU-UHFFFAOYSA-N | [SMILES]
S1(=O)(=O)C2=CC(Cl)=CC=C2NC(C)N1 |
| Hazard Information | Back Directory | [Chemical Properties]
white to off-white crystalline powder | [Uses]
IDRA-21 inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. IDRA-21 is more able to cross the blood-brain barrier than Cyclothiazide (C988960). | [Biological Activity]
Inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. More able to cross the blood-brain barrier than cyclothiazide (6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiazidiazine-7-sulfonamide-1,1-dioxide ). | [Definition]
ChEBI: 7-chloro-3-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine 1,1-dioxide is a benzothiadiazine. | [storage]
Store at RT |
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