| Identification | Back Directory | [Name]
1H-Pyrrole-3-carboxylic acid, 2,5-dihydro-5-oxo-2-phenyl-1-[4-(trifluoromethyl)phenyl]-4-[[4-(trifluoromethyl)phenyl]amino]-, ethyl ester | [CAS]
2250313-14-3 | [Synonyms]
Influenza A virus-IN-1
1H-Pyrrole-3-carboxylic acid, 2,5-dihydro-5-oxo-2-phenyl-1-[4-(trifluoromethyl)phenyl]-4-[[4-(trifluoromethyl)phenyl]amino]-, ethyl ester | [Molecular Formula]
C27H20F6N2O3 | [MOL File]
2250313-14-3.mol | [Molecular Weight]
534.45 |
| Chemical Properties | Back Directory | [Boiling point ]
567.1±50.0 °C(Predicted) | [density ]
1.406±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
-3.78±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Influenza A virus-IN-1 is a dihydropyrrolidones derivative and is a potent inhibitor against wide subtypes of influenza A virus (IAV) with IC50 values from 3.11 μM to 7.13 μM. Influenza A virus-IN-1 efficiently inhibits replication of IAV, up-regulates the expression of key antiviral cytokines IFN-β and antiviral protein MxA[1]. | [References]
[1] Teng Liu, et al. Discovery of Dihydropyrrolidones as Novel Inhibitors Against Influenza A Virus. Eur J Med Chem. 2020 Aug 1;199:112334. DOI:10.1016/j.ejmech.2020.112334 |
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