| Identification | Back Directory | [Name]
Nα-Fmoc-Nβ-pentynoyl-2,3-diaminopropionicacid,≥98%(Assaybytitration,HPLC) | [CAS]
2250436-47-4 | [Synonyms]
Fmoc-L-Dap(Pentynoyl)-OH
Nα-Fmoc-Nβ-pentynoyl-2,3-diaminopropionicacid,≥98%(Assaybytitration,HPLC)
L-Alanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-[(1-oxo-4-pentyn-1-yl)amino]- | [Molecular Formula]
C23H22N2O5 | [MOL File]
2250436-47-4.mol | [Molecular Weight]
406.43 |
| Chemical Properties | Back Directory | [Boiling point ]
712.4±60.0 °C(predicted) | [density ]
1.290±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
3.44±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
Fmoc-L-Dap(Pentynoyl)-OH is a click chemistry reagent containing an azide group. Fmoc-L-Dap(Pentynoyl)-OH serves as an amino acid building block for introducing alkyne functions into peptide sequences by standard Fmoc/tBu protocols. The alkyne residue can be engaged for copper catalyzed click reaction with organic azides or with tetrazines for copper-free conjugations[1]. Fmoc-L-Dap(Pentynoyl)-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [References]
[1] Le Chevalier Isaad A, et al. Side chain-to-side chain cyclization by click reaction. J Pept Sci. 2009 Jul;15(7):451-4. DOI:10.1002/psc.1141 |
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