ChemicalBook--->CAS DataBase List--->2251709-89-2

2251709-89-2

Request For Quotation

Directory

Chemical Properties

Hazard Information

2251709-89-2 Structure

2251709-89-2 Structure

Identification	Back Directory
[Name] PLK1/BRD4-IN-2
[CAS] 2251709-89-2
[Synonyms] PLK1/BRD4-IN-2
[Molecular Formula] C27H36N6O3
[MOL File] 2251709-89-2.mol
[Molecular Weight] 492.61

Chemical Properties	Back Directory
[Boiling point ] 762.477±70.00 °C(Press: 760.00 Torr)(predicted)
[density ] 1.242±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[form ] Solid
[pka] 6.519±0.40(predicted)

Hazard Information	Back Directory
[Uses] PLK1/BRD4-IN-2 (compound 15) is a BI-2536 (HY-50698) analog and dual inhibitor that targets both Polo-like kinase 1 (PLK1) and BRD4bromodomain (BRD4-BD1 IC50=28 nM, PLK1 IC50=40 nM)[1].
[IC 50] BRD4
[References] [1] Liu S, et al. Structure-Guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitors. J Med Chem. 2018 Sep 13;61(17):7785-7795.https://pubmed.ncbi.nlm.nih.gov/30125504/ DOI:10.1021/acs.jmedchem.8b00765

2251709-89-2 suppliers list

Company Name:	TargetMol Chemicals Inc.
Tel:	15002134094
Website:	https://www.targetmol.cn/

Tags:2251709-89-2 Related Product Information