| Identification | Back Directory | [Name]
RIPK1-IN-26 | [CAS]
2252271-96-6 | [Synonyms]
RIPK1-IN-26
1-Butanone, 1-(7-fluoro-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl)-2,2-dimethyl- | [Molecular Formula]
C15H20FNO2 | [MOL File]
2252271-96-6.mol | [Molecular Weight]
265.32 |
| Chemical Properties | Back Directory | [Boiling point ]
395.255±42.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.116±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
-0.653±0.20(predicted) |
| Hazard Information | Back Directory | [Uses]
RIPK1-IN-26 (Compound 8a) is a potent receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitor with cell anti-necroptosis potency. RIPK1-IN-26 demonstrats good metabolic stability and good binding specificity in mice. RIPK1-IN-26 is promising for research of PET imaging probe development and neurodegenerative disorders[1]. | [References]
[1] Luo T, et al. Design, synthesis, and preclinical evaluation of 11C/18F-labeled inhibitors for RIPK1 PET imaging. Eur J Med Chem. 2024 Sep 6;279:116851. DOI:10.1016/j.ejmech.2024.116851 |
|
|