| Identification | Back Directory | [Name]
TBAJ-587 | [CAS]
2252316-16-6 | [Synonyms]
TBAJ-587
Bacterial,Inhibitor,TBAJ-587,TBAJ587,inhibit,TBAJ 587 | [Molecular Formula]
C30H33BrFN3O5 | [MDL Number]
MFCD31813911 | [MOL File]
2252316-16-6.mol | [Molecular Weight]
614.51 |
| Chemical Properties | Back Directory | [Boiling point ]
710.8±60.0 °C(Predicted) | [density ]
1.349±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 43.33 mg/mL (70.51 mM; Need ultrasonic) | [form ]
Solid | [pka]
11?+-.0.29(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TBAJ-587, a potent anti-tuberculosis agent, inhibits M.tb strain H37Rv growth with MIC90s of 0.006 and <0.02 μg/mL in MABA and LORA assay, respectively. TBAJ-587 inhibits hERG channel minimally, attenuates inhibition of the cardiac potassium channel protein coded by the hERG, which is important for cardiac repolarization[1]. | [storage]
Store at -20°C | [References]
[1] Sutherland HS, et al. 3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel. Bioorg Med Chem. 2019 Apr 1;27(7):1292-1307. DOI:10.1016/j.bmc.2019.02.026 |
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| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|