| Identification | Back Directory | [Name]
1H-1,2,3-Triazole-4-butanoic acid, 1-(4-chlorophenyl)-, 1,4-dihydro-3-(3-methyl-2-buten-1-yl)-1,4-dioxo-2-naphthalenyl ester | [CAS]
2253635-71-9 | [Synonyms]
Antileishmanial agent-11
1H-1,2,3-Triazole-4-butanoic acid, 1-(4-chlorophenyl)-, 1,4-dihydro-3-(3-methyl-2-buten-1-yl)-1,4-dioxo-2-naphthalenyl ester | [Molecular Formula]
C27H24ClN3O4 | [MOL File]
2253635-71-9.mol | [Molecular Weight]
489.95 |
| Hazard Information | Back Directory | [Uses]
Antileishmanial agent-11 (compound 4d) is a potent anti-leishmanial agent. Antileishmanial agent-11 shows antiprotozoal activity against Leishmania brazilensis, Leishmania infantum, and T. cruzi, with IC50 values of 28.3, 24.8 and 13.0 μM, respectively[1]. | [References]
[1] Pertino MW, et al. Synthesis, trypanocidal and anti-leishmania activity of new triazole-lapachol and nor-lapachol hybrids. Bioorg Chem. 2020 Oct;103:104122. DOI:10.1016/j.bioorg.2020.104122 |
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