| Identification | Back Directory | [Name]
1-Piperidinecarboxylic acid, 4-[[3,4-dioxo-2-[[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]amino]-1-cyclobuten-1-yl]amino]-, ethyl ester, hydrochloride (1:1) | [CAS]
2253744-55-5 | [Synonyms]
1-Piperidinecarboxylic acid, 4-[[3,4-dioxo-2-[[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]amino]-1-cyclobuten-1-yl]amino]-, ethyl ester, hydrochloride (1:1) | [Molecular Formula]
C25H33ClF3N5O4 | [MOL File]
2253744-55-5.mol | [Molecular Weight]
560.02 |
| Hazard Information | Back Directory | [Uses]
Squarunkin A hydrochloride is a potent and selective UNC119-cargo interaction inhibitor (IC50 of 10 nM for inhibiting the UNC119A-myristoylated Src N-terminal peptide interaction). Squarunkin A hydrochloride interferes with the activation of Src kinase in cells[1]. | [Biological Activity]
Squarunkin A hydrochloride is a potent inhibitor of UNC119 chaperone protein-cargo interaction (IC50 = 10 nM for inhibition of UNC119A - myristoylated Src N-terminal peptide interaction). Disrupts activation of Src kinase in vitro. | [storage]
Store at -20°C | [References]
[1] Tom Mejuch, et al. Small-Molecule Inhibition of the UNC119-Cargo Interaction. Angew Chem Int Ed Engl. 2017 May 22;56(22):6181-6186. DOI:10.1002/anie.201701905 |
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