| Identification | Back Directory | [Name]
5,8-Dioxa-2,11-diazatridecanoic acid, 13-(aminooxy)-12-oxo-, bicyclo[6.1.0]non-4-yn-9-ylmethyl ester | [CAS]
2253965-14-7 | [Synonyms]
aminooxy-PEG2-BCN
5,8-Dioxa-2,11-diazatridecanoic acid, 13-(aminooxy)-12-oxo-, bicyclo[6.1.0]non-4-yn-9-ylmethyl ester | [Molecular Formula]
C19H31N3O6 | [MOL File]
2253965-14-7.mol | [Molecular Weight]
397.47 |
| Hazard Information | Back Directory | [Uses]
Aminooxy-PEG2-BCN is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminooxy-PEG2-BCN is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | [IC 50]
Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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