| Identification | Back Directory | [Name]
SJFδ | [CAS]
2254609-23-7 | [Synonyms]
SJFΔ
1,1-Cyclopropanedicarboxamide, N-[4-[[7-[2-[2-[2-[2-[[[[(2S,4R)-1-[(2S)-2-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-3-methyl-1-oxobutyl]-4-hydroxy-2-pyrrolidinyl]carbonyl]amino]methyl]-5-(4-methyl-5-thiazolyl)phenoxy]ethoxy]ethoxy]ethoxy]-6-methoxy-4-quinolinyl]oxy]-3-fluorophenyl]-N'-(4-fluorophenyl)- | [Molecular Formula]
C62H63F2N7O12S | [MDL Number]
MFCD31813760 | [MOL File]
2254609-23-7.mol | [Molecular Weight]
1168.27 |
| Hazard Information | Back Directory | [Uses]
SJFδ is a 10-atom linker PROTAC based on von Hippel-Lindau ligand. SJFδ degrades p38δ with a DC50 of 46.17?nM, but does not degrade p38α, p38β, or p38γ[1]. | [IC 50]
p38α: 46.17 nM (DC50); VHL | [storage]
Store at -20°C | [References]
[1] Smith BE, et al. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat Commun. 2019 Jan 10;10(1):131. DOI:10.1038/s41467-018-08027-7 |
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