| Identification | Back Directory | [Name]
3-Chloro-4,6-dihydroxy-2-methyl-5-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrienyl]benzaldehyde | [CAS]
22581-06-2 | [Synonyms]
Ilicicolin A
3-Chloro-4,6-dihydroxy-2-methyl-5-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrienyl]benzaldehyde | [MOL File]
22581-06-2.mol |
| Hazard Information | Back Directory | [Uses]
Ilicicolin A is a potent anticancer agent. Ilicicolin A induces apoptosis. Ilicicolin A inhibits cell growth and colony formation. Ilicicolin A shows antitumor activity. Ilicicolin A has the potential for the research of prostate cancer[1]. | [in vivo]
Ilicicolin A (10 mg/kg; i.p.; six times a week for 3 weeks) inhibits tumor growth in mice[1]. | Animal Model: | Four-week-old, 18 g, male NOD/SCID mice (22Rv1 cells) [1] | | Dosage: | 10 mg/kg | | Administration: | I.p.; six times a week for 3 weeks | | Result: | Suppressed tumor growth but did not elicit a significant effect on bodyweight. |
| [References]
[1] Guo L, et al. Ilicicolin A Exerts Antitumor Effect in Castration-Resistant Prostate Cancer Via Suppressing EZH2 Signaling Pathway. Front Pharmacol. 2021 Oct 27;12:723729. DOI:10.3389/fphar.2021.723729 |
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