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2259318-46-0

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2259318-46-0 Structure

2259318-46-0 Structure
IdentificationBack Directory
[Name]

SC-VC-PAB-MMAE
[CAS]

2259318-46-0
[Synonyms]

SC-VC-PAB-MMAE
[Molecular Formula]

C68H105N11O17
[MDL Number]

MFCD32689556
[MOL File]

2259318-46-0.mol
[Molecular Weight]

1348.62
Chemical PropertiesBack Directory
[density ]

1.25±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

13.29±0.70(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]

Skull and Crossbones (GHS06)Health Hazard (GHS08)
GHS06,GHS08
[Signal word ]

Danger
[Hazard statements ]

H300+H330-H340-H360-H370-H372-H412
[Precautionary statements ]

P260-P264-P270-P304+P340
Hazard InformationBack Directory
[Uses]

SC-VC-PAB-MMAE is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker SC-VC-PAB[1].
[IC 50]

Auristatin
[References]

[1] Brian Lannutti, et al. Ror1 antibody immunoconjugates. WO2018237335A1.
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