| Identification | Back Directory | [Name]
2-Pyrrolidinecarboxamide, N-1H-indazol-4-yl-1-[[1-(4-methoxyphenyl)cyclopentyl]carbonyl]-, (2R)- | [CAS]
2259640-87-2 | [Synonyms]
CBP/p300-IN-17
2-Pyrrolidinecarboxamide, N-1H-indazol-4-yl-1-[[1-(4-methoxyphenyl)cyclopentyl]carbonyl]-, (2R)- | [Molecular Formula]
C25H28N4O3 | [MOL File]
2259640-87-2.mol | [Molecular Weight]
432.51 |
| Hazard Information | Back Directory | [Uses]
CBP/p300-IN-17 (compound 7) is a potent EP300/CBP HAT inhibitor with IC50s of 0.18, 0.69 μM for HAT EP300 and LK2 H3K27, respectively[1]. | [IC 50]
EP300: .18 μM (IC50); LK2 H3K27: 0.69 μM (IC50) | [References]
[1] Kanada R, et al. Discovery of EP300/CBP histone acetyltransferase inhibitors through scaffold hopping of 1,4-oxazepane ring. Bioorg Med Chem Lett. 2022 Jun 15;66:128726. DOI:10.1016/j.bmcl.2022.128726 |
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