| Identification | Back Directory | [Name]
Acetiromate | [CAS]
2260-08-4 | [Synonyms]
Adecol
Acetiromate
Acetyltriiodothyroformic acid
3,5-Diiodo-4-(4-acetoxy-3-iodophenoxy)benzoic acid
4-(4-Acetoxy-3-iodophenoxy)-3,5-diiodobenzoic acid
4-(4-acetyloxy-3-iodophenoxy)-3,5-diiodobenzoic acid
4-(4-acetyloxy-3-iodo-phenoxy)-3,5-diiodo-benzoic acid | [Molecular Formula]
C15H9I3O5 | [MDL Number]
MFCD00865720 | [MOL File]
2260-08-4.mol | [Molecular Weight]
649.931 |
| Hazard Information | Back Directory | [Originator]
Acetiromate ,ZYF Pharm Chemical | [Uses]
Acetiromate is a thyroxine analogue. Acetiromate is an antilipidemic drug for hyperlipidemia[1]. | [Manufacturing Process]
To 3 parts of 3,5-diiodo-4-(3-iodo-4-hydroxyphenoxy)benzoic acid 10 parts of
acetic acid anhydride was added and mixture was heated on oil bath for some
hours. In the result of this reaction amorphous precipitate was obtained. After
recrystallization from glacial acetic acid 2.4 parts of 3,5-diiodo-4-(3-iodo-4-
acetoxyphenoxy)benzoic acid were obtained. | [Therapeutic Function]
Antihyperlipidemic | [References]
[1] S Kumaoka. Long-term administration of 3,5-diodo-4(3'-iodo4'-acetoxyphenoxy) benzoic acid (acetiromate) in hyperlipidemic patients. Endocrinol Jpn. 1974 Aug;21(4):355-60. DOI:10.1507/endocrj1954.21.355 |
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