| Identification | Back Directory | [Name]
Phosphonic acid, P,P'-[[[4-(hexyloxy)-2-pyridinyl]amino]methylene]bis- | [CAS]
2260887-09-8 | [Synonyms]
TH-Z93
Phosphonic acid, P,P'-[[[4-(hexyloxy)-2-pyridinyl]amino]methylene]bis- | [Molecular Formula]
C12H22N2O7P2 | [MOL File]
2260887-09-8.mol | [Molecular Weight]
368.26 |
| Chemical Properties | Back Directory | [Boiling point ]
693.4±65.0 °C(Predicted) | [density ]
1.488±0.06 g/cm3(Predicted) | [solubility ]
soluble (H2O + 1 drop 5M NaOH, 2 mg/mL, clear) | [form ]
Solid | [pka]
1.17±0.10(Predicted) | [color ]
White to off-white | [SMILES]
O=P(O)(C(P(O)(O)=O)NC1=NC=CC(OCCCCCC)=C1)O |
| Hazard Information | Back Directory | [Uses]
TH-Z93, a lipophilic bisphosphonate, is a FPPS inhibitor (IC50: 90 nM)[1]. | [in vivo]
TH-Z93 (20 μg, i.p.) exhibits strong prophylactic effects in a pathogenic influenza model[1].
| Animal Model: | B16-OVA cells (s.c.) xenograft mice model[1]. | | Dosage: | 20 μg | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Inhibited tumor growth and prolonged survival. |
| [References]
[1] Xia Y, et al. The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery. Cell. 2018 Nov 1;175(4):1059-1073.e21. DOI:10.1016/j.cell.2018.08.070 |
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