| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 10 mg/mL; DMSO: 10 mg/mL; DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL; Ethanol: 1 mg/mL | [form ]
A crystalline solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Tauro-α-muricholic acid (TαMCA) is an antagonist of the farnesoid X receptor (FXR; IC50 = 28 μM) and a taurine-conjugated form of the murine-specific primary bile acid α-muricholic acid .1 TαMCA is common in rodents but has also been found in small amounts in human serum.2
| [Uses]
Tauro-α-muricholic acid (T-α-MCA) sodium is a FXR (Farnesoid X receptor) antagonist (IC50=28μM). Tauro-α-muricholic acid sodium is also a endogenous metabolite that can be found in cecal[1][2]. | [IC 50]
Microbial Metabolite | [References]
1. Sayin, S.I., Wahlstr?m, A., Felin, J., et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist Cell Metab. 17(2),225-235(2013).
2. García-Ca?averas, J.C., Donato, M.T., Castell, J.V., et al. Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method J. Lipid Res. 53(10),2231-2241(2012). |
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