| Identification | Back Directory | [Name]
1H-Imidazo[4,5-g]quinoxaline, 1,2-dimethyl-6-(2-thienyl)- | [CAS]
226717-28-8 | [Synonyms]
1H-Imidazo[4,5-g]quinoxaline, 1,2-dimethyl-6-(2-thienyl)- | [Molecular Formula]
C15H12N4S | [MDL Number]
MFCD06411387 | [MOL File]
226717-28-8.mol | [Molecular Weight]
280.35 |
| Hazard Information | Back Directory | [Uses]
AGL 2043 is an effective inhibitor of PDGFR (IC50=0.8 μM) and TEL-PDGFR kinases, as well as FLT3 and KIT kinases. AGL 2043 can effectively inhibit porcine cardiac smooth muscle cell proliferation and balloon-induced vascular stenosis, and is suitable for development as an anti-restenotic and anticancer agent[1]. | [References]
[1] Gazit A, et al. Tricyclic quinoxalines as potent kinase inhibitors of PDGFR kinase, Flt3 and Kit. Bioorg Med Chem. 2003;11(9):2007-2018. DOI:10.1016/s0968-0896(03)00048-8 |
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