| Identification | Back Directory | [Name]
Quinoxaline, 2-chloro-3-[(phenylsulfonyl)methyl]- | [CAS]
227002-04-2 | [Synonyms]
L764406
L-764406
L 764406
Quinoxaline, 2-chloro-3-[(phenylsulfonyl)methyl]- | [Molecular Formula]
C15H11ClN2O2S | [MOL File]
227002-04-2.mol | [Molecular Weight]
318.78 |
| Hazard Information | Back Directory | [Description]
L-764406 is a partial agonist of human peroxisome proliferator-activated receptor gamma. | [Uses]
L-764406 is a non-thiazolidinedione (TZD)-type PPARg nuclear receptor ligand with high affinity. L-764406 has significant binding ability to PPARg (IC50=70 nM). L-764406 exhibited partial agonist activity and induced expression of the adipocyte-specific gene aP2 in chimeric receptors expressing the PPARg LBD and the corresponding reporter gene, as well as in 3T3-L1 cells. In contrast, L-764406 showed no activity in cells transfected with chimeric receptors containing PPARa or PPARd LBDs[1]. | [References]
[1] L-764406 Is a Partial Agonist of Human Peroxisome Proliferator-activated Receptor g |
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