| Identification | Back Directory | [Name]
Urea, N-(5-amino-2-fluoro-4-pyridinyl)-N′-[3-(difluoromethyl)-5-isothiazolyl]- | [CAS]
2270875-93-7 | [Synonyms]
Urea, N-(5-amino-2-fluoro-4-pyridinyl)-N′-[3-(difluoromethyl)-5-isothiazolyl]- | [Molecular Formula]
C10H8F3N5OS | [MOL File]
2270875-93-7.mol | [Molecular Weight]
303.27 |
| Chemical Properties | Back Directory | [Boiling point ]
317.9±42.0 °C(predicted) | [density ]
1.682±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
11.59±0.70(predicted) |
| Hazard Information | Back Directory | [Uses]
SMARCA2-IN-8 (Compound 13) is an orally active inhibitor for SWI/SNF chromatin remodeling complexe SMARCA2 (also known as Brahma homologue, BRM) and SMARCA4 (also known as Brahma-related gene 1, BRG1) with IC50 of 5 and 6 nM. SMARCA2-IN-8 inhibits the proliferation of SMARCA2 mutated cancer cell SKMEL5 with AAC50 of 5 nM. SMARCA2-IN-8 downregulates the SMARCA2-dependent KRT80 gene expression with AAC50 of 10 nM. SMARCA2-IN-8 exhibits antitumor efficacy and good pharmacokinetic characteristics in mice[1]. | [References]
[1] Papillon JPN, et al., Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. J Med Chem. 2018 Nov 21;61(22):10155-10172. DOI:10.1021/acs.jmedchem.8b01318 |
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