| Identification | Back Directory | [Name]
AL284 | [CAS]
2270876-07-6 | [Synonyms]
AL284
Ethanone, 1-[4-(4-ethyl-1-piperazinyl)-1-piperidinyl]-2-[(4′-methoxy[1,1′-biphenyl]-4-yl)oxy]- | [Molecular Formula]
C26H35N3O3 | [MOL File]
2270876-07-6.mol | [Molecular Weight]
437.58 |
| Chemical Properties | Back Directory | [Boiling point ]
618.1±55.0 °C(predicted) | [density ]
1.132±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
8.07±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
AL284 is a potent anopheles gambiae acetylcholinesterase 1 (AgAChE1) inhibitor. AL284 interactions with Tyr489Ag in the α-helix next to loop 2, and Trp441Ag at the top of the gorge. AL284 has the potential for the research of disease-transmitting mosquitoes[1]. | [IC 50]
AChE | [References]
[1] Kumari R, et al. Enzyme Dynamics Determine the Potency and Selectivity of Inhibitors Targeting Disease-Transmitting Mosquitoes. ACS Infect Dis. 2024 Oct 11;10(10):3664-3680. DOI:10.1021/acsinfecdis.4c00531 |
|
|