| Identification | Back Directory | [Name]
IA-14069 | [CAS]
2271216-04-5 | [Synonyms]
IA-14069
4H-1-Benzopyran-3-carboxylic acid, 7-chloro-2-(2,5-difluorophenyl)-4-oxo-, 1,1-dimethylethyl ester | [Molecular Formula]
C20H15ClF2O4 | [MOL File]
2271216-04-5.mol | [Molecular Weight]
392.78 |
| Chemical Properties | Back Directory | [Boiling point ]
487.0±45.0 °C(Predicted) | [density ]
1.379±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20℃ | [solubility ]
Soluble in DMSO | [form ]
Solid | [color ]
White to off-white | [InChI]
InChI=1S/C20H15ClF2O4/c1-20(2,3)27-19(25)16-17(24)12-6-4-10(21)8-15(12)26-18(16)13-9-11(22)5-7-14(13)23/h4-9H,1-3H3 | [InChIKey]
FWIGHXSYEQALSL-UHFFFAOYSA-N | [SMILES]
C1(C2=CC(F)=CC=C2F)OC2=CC(Cl)=CC=C2C(=O)C=1C(OC(C)(C)C)=O |
| Hazard Information | Back Directory | [Uses]
IA-14069 is an orally active TNF-α inhibitor for studies related to rheumatoid arthritis. | [Biological Activity]
IA-14069 potently inhibits both TNF-α-induced cytotoxicity (IC50 < 0.7 μM), which directly binds to TNF-α and TNF-α-triggered signaling (p-IκBα and NF-κB p65) activities. The therapeutic and preventive anti-RA effects of IA-14069 were demonstrated in TNF-α-TG and CIA models. IA-14069 and MTX had synergistic effects in the CIA therapeutic model. According to pharmacokinetic analysis, IA-14069 showed significant bioavailability. In addition, no in vivo toxicity was observed even under treatment with an excessive amount of IA-14069[1].
| [References]
[1] Sung-Dong Park. “THU0047 IA-14069, A NOVEL SMALL-MOLECULE INHIBITOR DIRECT-TARGETING TUMOR NECROSIS FACTOR-α, ATTENUATES COLLAGEN INDUCED ARTHRITIS.” Annals of the Rheumatic Diseases 78 1 (2019): 291–291. |
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TargetMol
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www.targetmol.cn/ |
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