| Identification | Back Directory | [Name]
2,5-Diaminopyrimidine | [CAS]
22715-27-1 | [Synonyms]
2,5-DIAMINOPYRIMIDINE
2,5-Pyrimidinediamine
2,5-Diaminepyrimidine
pyrimidine-2,5-diamine
Pyrimidine, 2,5-diamino-
2,5-Pyrimidinediamine (9CI)
(2-aminopyrimidin-5-yl)amine
2,5-Diaminopyrimidine ISO 9001：2015 REACH | [Molecular Formula]
C4H6N4 | [MDL Number]
MFCD00129726 | [MOL File]
22715-27-1.mol | [Molecular Weight]
110.12 |
| Chemical Properties | Back Directory | [Melting point ]
200 °C | [Boiling point ]
401.7±37.0 °C(Predicted) | [density ]
1.368±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [pka]
4.83±0.10(Predicted) | [Appearance]
Yellow to brown Solid |
| Hazard Information | Back Directory | [Synthesis]
Synthesis of I-5: To a 1L round bottom flask was added 5-nitropyrimidin-2-amine (30 g, 214.13 mmol, 1.00 eq.), methanol (400 mL) and palladium carbon (12 g). The reaction mixture was stirred overnight at room temperature in a hydrogen atmosphere. Upon completion of the reaction, the solid catalyst was removed by filtration. The filtrate was concentrated under reduced pressure to afford pyrimidine-2,5-diamine (20 g, 85% yield) as a light brown solid. | [References]
[1] Patent: US7235559, 2007, B1
[2] Patent: US2014/275119, 2014, A1. Location in patent: Paragraph 0416
[3] Journal of the American Chemical Society, 1942, vol. 64, p. 2340
[4] Journal of Medicinal Chemistry, 2008, vol. 51, # 6, p. 1681 - 1694
[5] Patent: WO2010/111483, 2010, A1. Location in patent: Page/Page column 90 |
|
|