ChemicalBook--->CAS DataBase List--->2274802-95-6

2274802-95-6

2274802-95-6 Structure

2274802-95-6 Structure
IdentificationBack Directory
[Name]

Methanesulfonamide, N-[(2S,3S)-1-(2-hydroxy-2-methyl-1-oxopropyl)-2-[(2,3',5'-trifluoro[1,1'-biphenyl]-3-yl)methyl]-3-pyrrolidinyl]-
[CAS]

2274802-95-6
[Synonyms]

Firazorexton
Methanesulfonamide, N-[(2S,3S)-1-(2-hydroxy-2-methyl-1-oxopropyl)-2-[(2,3',5'-trifluoro[1,1'-biphenyl]-3-yl)methyl]-3-pyrrolidinyl]-
[Molecular Formula]

C22H25F3N2O4S
[MOL File]

2274802-95-6.mol
[Molecular Weight]

470.51
Chemical PropertiesBack Directory
[Boiling point ]

605.5±65.0 °C(Predicted)
[density ]

1.39±0.1 g/cm3(Predicted)
[solubility ]

Acetonitrile: Slightly Soluble: 0.1-1 mg/mL
DMSO: Sparingly Soluble: 1-10 mg/mL
[form ]

Solid
[pka]

9.62±0.40(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Firazorexton (TAK-994 free base) is an orally active and brain-penetrant orexin type 2 receptor (OX2R) selective agonist. Firazorexton (TAK-994 free base) can promote wakefulness and has the potential to improve narcolepsy-like symptoms in mice[1].
[in vivo]

Firazorexton (oral administration; 30 mg/kg; single dose) can increase the total wakefulness time in C57BL/6J mice[1].
Firazorexton (oral administration; 3-10 mg/kg; single dose) can improve narcolepsy-like symptoms in mouse models of narcolepsy[1].

Animal Model:Orexin/ataxin-3 mice model[1]
Dosage:3 and 10 mg/kg
Administration:Oral administration (p.o.); single dose
Result:Significantly increased total wakefulness time.
Decreased total NREM sleep time and REM sleep time.
Significantly ameliorated fragmentation of wakefulness with fewer number of wakefulness episodes and longer mean duration of wakefulness episodes.
Significantly increased gamma power during wakefulness at dose of 10 mg/kg.
[IC 50]

OX2 Receptor
[References]

[1] Ishikawa T, et al. TAK-994, a Novel Orally Available Brain-Penetrant Orexin 2 Receptor-Selective Agonist, Suppresses Fragmentation of Wakefulness and Cataplexy-Like Episodes in Mouse Models of Narcolepsy. J Pharmacol Exp Ther. 2023 Jun;385(3):193-204. DOI:10.1124/jpet.122.001449
2274802-95-6 suppliers list
Company Name: ShangHai Caerulum Pharma Discovery Co., Ltd.  
Tel: 18149758185
Website: www.caerulumpharma.com
Company Name: Shanghai Chaolan Chemical Technology Center  
Tel: 021-QQ:65489617 15618227136
Website: www.atkchemical.com/
Company Name: ShangHai ChuanQian Chemcial Technique Centre  
Tel: 15869524721
Website: www.chemicalbook.com/ShowSupplierProductsList68594/0_EN.htm
Company Name: Bide Pharmatech Ltd.  
Tel: 400-1647117 13681763483
Website: https://www.bidepharm.com/
Company Name: TargetMol Chemicals Inc.  
Tel: 4008200310
Website: https://www.targetmol.cn/
Company Name: Nantong QuanYi Biotechnology Co., Ltd  
Tel: 0513-66337626 18051384581
Website: https://www.chemhifuture.com/
Company Name: Cayman Chemical Company  
Tel: 800-364-9897
Website: www.caymanchem.com
Tags:2274802-95-6 Related Product Information

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.