| Identification | Back Directory | [Name]
Aclerastide | [CAS]
227803-63-6 | [Synonyms]
DSC127
DSC-127
DSC 127
Aclerastide
NorLeu-3A(1-7)
NorLeu-3-A(1-7)
1-7-Angiotensin II, 3-L-norleucine-5-L-isoleucine- | [Molecular Formula]
C42H64N12O11 | [MOL File]
227803-63-6.mol | [Molecular Weight]
913.031 |
| Chemical Properties | Back Directory | [density ]
1.45±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
3.29±0.20(Predicted) | [color ]
White to off-white | [Sequence]
Asp-Arg-{Nle}-Tyr-Ile-His-Pro |
| Hazard Information | Back Directory | [Uses]
Aclerastide is a peptide analog of angiotensin II, and a potential treatment for diabetic foot ulcers. | [in vivo]
Aclerastide (0.1 mg/wound; day for 5 days) shows superior efficacy in the db/db mouse model of wound healing[1].
Aclerastide (topically administered; 100 μL; once a day; for 14 days) elevates levels of reactive oxygen species and of active MMP-9[2]. | Animal Model: | db/db mice[2] | | Dosage: | 100 μL | | Administration: | Topically administered, once a day, for 14 days | | Result: | Upregulated reactive oxygen species during inflammation.
Increased the levels of the detrimental active MMP-9 in diabetic wounds.
|
|
|
| Company Name: |
YantaiBio
|
| Tel: |
13758194781 15083780366 |
| Website: |
|
| Company Name: |
Fuan Bio
|
| Tel: |
18178976185 |
| Website: |
|
| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
|