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2283356-12-5

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2283356-12-5 Structure

2283356-12-5 Structure
IdentificationBack Directory
[Name]

1H-Cyclopropa[3,4]cyclopenta[1,2-c]pyrazole-1-acetamide, N-[(1S)-1-[3-[4-chloro-3-[(methylsulfonyl)amino]-1-(2,2,2-trifluoroethyl)-1H-indazol-7-yl]-6-[3-methyl-3-(methylsulfonyl)-1-butyn-1-yl]-2-pyridinyl]-2-(3,5-difluorophenyl)ethyl]-5,5-difluoro-3b,4,4a,5-tetrahydro-3-(trifluoromethyl)-, sodium salt (1:1), (3bS,4aR)-
[CAS]

2283356-12-5
[Synonyms]

Lenacapavir sodium
1H-Cyclopropa[3,4]cyclopenta[1,2-c]pyrazole-1-acetamide, N-[(1S)-1-[3-[4-chloro-3-[(methylsulfonyl)amino]-1-(2,2,2-trifluoroethyl)-1H-indazol-7-yl]-6-[3-methyl-3-(methylsulfonyl)-1-butyn-1-yl]-2-pyridinyl]-2-(3,5-difluorophenyl)ethyl]-5,5-difluoro-3b,4,4a,5-tetrahydro-3-(trifluoromethyl)-, sodium salt (1:1), (3bS,4aR)-
[Molecular Formula]

C39H33ClF10N7NaO5S2
[MOL File]

2283356-12-5.mol
[Molecular Weight]

992.28
Chemical PropertiesBack Directory
[InChIKey]

YQAVPMRAVXDNPU-JUXSWVSFNA-N
Hazard InformationBack Directory
[Uses]

Lenacapavir (GS-6207) sodium is a HIV-1 capsid inhibitor. Lenacapavir sodium shows anti-HIV activity with an EC50 of 100 pM in MT-4 cells. Lenacapavir sodium displays a mean EC50 of 50 pM (20-160 pM) against 23 HIV-1 clinical isolates from different subtypes in peripheral blood mononuclear cells (PBMCs)[1].
[References]

[1] Singh K, et al. GS-CA Compounds: First-In-Class HIV-1 Capsid Inhibitors Covering Multiple Grounds. Front Microbiol. 2019 Jun 20;10:1227. DOI:10.3389/fmicb.2019.01227
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