| Identification | Back Directory | [Name]
Urea, N-[3-(1,1-dimethylethyl)-1-methyl-1H-pyrazol-5-yl]-N'-[4-(4-pyridinyloxy)phenyl]- | [CAS]
229002-10-2 | [Synonyms]
MAPK13-IN-1
MAPK13 inhibitor 1
Urea, N-[3-(1,1-dimethylethyl)-1-methyl-1H-pyrazol-5-yl]-N'-[4-(4-pyridinyloxy)phenyl]- | [Molecular Formula]
C20H23N5O2 | [MDL Number]
MFCD30533529 | [MOL File]
229002-10-2.mol | [Molecular Weight]
365.43 |
| Chemical Properties | Back Directory | [Boiling point ]
450.2±45.0 °C(Predicted) | [density ]
1.20±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥ 250 mg/mL (684.13 mM) | [form ]
Solid | [pka]
13.59±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
MPAK13-IN-1 is a MAPK13 (p38δ) inhibitor, with an IC50 of 620 nM. | [IC 50]
MAPK13 (p38δ): 620 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Yurtsever Z, et al. First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes. Biochim Biophys Acta. 2016 Nov;1860(11 Pt A):2335-2344. DOI:10.1016/j.bbagen.2016.06.023
[2] Mehdi Bouhaddou, et al. The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell. 2020 Aug 6;182(3):685-712.e19. DOI:10.1016/j.cell.2020.06.034 |
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