| Identification | Back Directory | [Name]
Propanoic acid, 3-[2-[2-[[2-[4-[[[[5-(1,1-dimethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]imidazo[2,1-b]benzothiazol-7-yl]oxy]ethoxy]ethoxy]- | [CAS]
2292116-14-2 | [Synonyms]
Desmorpholinyl Quizartinib-PEG2-COOH
Propanoic acid, 3-[2-[2-[[2-[4-[[[[5-(1,1-dimethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]imidazo[2,1-b]benzothiazol-7-yl]oxy]ethoxy]ethoxy]- | [Molecular Formula]
C30H33N5O7S | [MOL File]
2292116-14-2.mol | [Molecular Weight]
607.68 |
| Hazard Information | Back Directory | [Uses]
Desmorpholinyl Quizartinib-PEG2-COOH incorporates a ligand for FLT-3, and a PEG-based PROTAC linker. Desmorpholinyl Quizartinib-PEG2-COOH can be used in the synthesis of PROTAC FLT-3 degrader 1 (HY-114323). PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM[1]. | [References]
[1] Burslem GM, et al. Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. J Am Chem Soc. 2018 Dec 5;140(48):16428-16432. DOI:10.1021/jacs.8b10320 |
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